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邵峰
中国科学院院士，北京生命科学研究所学术副所长
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详细介绍
邵峰
中国科学院院士，北京生命科学研究所学术副所长
个人履历：
邵峰：男，1972年1月出生，江苏淮安人，生物化学家，中国科学院院士，美国微生物学院会士，北京生命科学研究所学术副所长、资深研究员，清华大学讲席教授和昌平实验室副主任，第十四届全国政协委员，国家杰出青年科学基金获得者，入选国家创新人才推进计划，国家“万人计划”领军人才。兼任《BMC Microbiology》、编委《PNAS》编委《eLife》编委、《Cellular Microbiology》编委 、《中国科学：生命科学》编委。1996年邵峰毕业于北京大学技术物理系应用化学专业；1999年获得中国科学院生物物理研究所硕士学位；2003年获得美国密歇根大学医学院博士学位，之后进入加利福尼亚大学圣迭戈分校医学院进行博士后研究工作；2004年进入哈佛大学医学院进行博士后研究；2005年回国后进入北京生命科学研究所工作，先后担任研究员、高级研究员、资深研究员。邵峰院士主要从事病原菌和宿主相互作用的机理研究，在病原菌毒力机制和抗细菌天然免疫领域取得系列重要原创性发现。已发表论文50多篇，被国际同行引用4000多次，他以通讯作者身份在《自然》《科学》《细胞》等三大国际顶级学术期刊上发表论文9篇，研究成果多次被专家和学术杂志重点评述。2013年作为首位大陆本土科学家获得国际蛋白质学会颁发的鄂文·西格青年科学家奖；2014年入选国家创新人才推进计划；2015年当选为中国科学院生命科学和医学学部院士；2016年入选第二批国家“万人计划”领军人才；2017年获得中国细胞生物学学会杰出成就奖。2019年获得未来科学大奖“生命科学奖”。2022年度陈嘉庚科学奖生命科学奖。
论文代表：
(2023) Structural mechanisms for regulation of GSDMB pore-forming activity. Nature, 616, 598-605.
(2012) NLRC5: a NOD-like receptor protein with many faces in immune regulation. Cell Research, 22, 1099-101.
(2012) Sensing bacterial infections by NAIP receptors in NLRC4 inflammasome activation. Protein & Cell, 3, 98-105.
(2012) Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses. Cell, 150, 1029-41.
(2012) Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking. Proc. Natl. Acad. Sci., 109, 6193-8.
(2012) Cysteine methylation disrupts ubiquitin-chain sensing in NF-kB activation. Nature, 481, 204-8.
(2011) Manipulation of host vesicular trafficking and innate immune defense by Legionella Dot/Icm effectors. Cell. Microbiol., 13, 1870-80.
(2011) Biochemistry and cell signaling taught by bacterial effectors. Trends in Biochemical Sciences, 36, 532-40.
(2011)The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature, 477, 596–600.
(2010) Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science, 329, 1215-8.
(2010) Chemical probing reveals insights into the signaling mechanism of inflammasome activation. Cell Research, 20, 1289-305.
(2010) A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis. EMBO J., 29, 1363-76.
(2010) Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA. Proc. Natl. Acad. Sci., 107, 4699-704.
(2009)A Legionella type IV effector activates the NF-κB pathway by phosphorylating the IκB family of inhibitors. Proc. Natl. Acad. Sci., 106, 13725-30.
(2009) Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. Mol. Cell, 35, 841-55.
(2009) A bacterial type III effector family uses the papain-like hydrolytic activity to arrest the host cell cycle. Proc. Natl. Acad. Sci., 106, 3716-21.
(2008) Structure of a Shigella effector reveals a new class of ubiquitin ligases. Nature Structural & Molecular Biology, 15, 1302-8.
(2008) Biochemical functions of Yersinia type III effectors. Current Opinion in Microbiology, 11, 21-9.
(2007) Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase. Mol. Cell, 28, 899-913.
(2007) A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced immunity. Cell Host & Microbe, 1, 175-85.
(2007) The phosphothreonine lyase activity of a bacterial type III effector family. Science, 315, 1000-3.
(2006) Identification of a bacterial type III effector family with G-protein mimicry functions. Cell, 124, 133-45.
(2004) The crystal structure of Pseudomonas avirulence protein AvrPphB: a papain-like fold with a distinct substrate-binding site. Proc. Natl. Acad. Sci., 101, 302-7.
(2003) Cleavage of Arabidopsis PBS1 by a bacterial type III effector. Science, 301, 1230-3.
(2003) Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPases. Proc. Natl. Acad. Sci., 100, 904-9.
(2002) A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis. Cell, 109, 575-88.
(2000) DsbG, a protein disulfide isomerase with chaperone activity. J. Biol. Chem., 275, 13349-52.
(1999) A new antifungal peptide from the seeds of Phytolacca americana: characterization, amino acid sequence and cDNA cloning. Biochim. Biophys. Acta, 1430, 262-8.
(1999) Expression and purification of the BmK M1 neurotoxin from the scorpion Buthus martensii Karsch. Protein Expr. Purif., 17, 358-65.
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