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郭子建
中国科学院院士，南京大学化学化工学院教授
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详细介绍
郭子建
中国科学院院士，南京大学化学化工学院教授
个人履历：
郭子建：男，1961年10月出生，河北河间人，化学生物学家，中国科学院院士、发展中国家科学院院士，英国皇家化学会会士，南京大学教授、博士生导师，南京大学化学和生物医药创新研究院院长，南京大学新生学院院长，南京大学学术委员会副主任，配位化学国家重点实验室（南京大学）学委会副主任，教育部长江学者奖励计划特聘教授，享受国务院政府特殊津贴。兼任：国务院学位委员会学科评议组（化学）成员，教育部科技委员会委员化学化工学部委员，中国化学会常务理事。担任爱思唯尔CoordChem Rev副主编，中国化学会《无机化学学报》主编，以及NatSci Rev, Dalton Trans等国内外多家学术期刊编委或顾问编委等。1989年11月-1994年，意大利帕多瓦大学学习，获博士学位；1994年9月-1996年6月，英国伦敦大学，博士后；1996年6月-1996年10月，加拿大不列颠哥伦比亚大学，访问学者；1996年9月-1999年5月，英国爱丁堡大学，研究助理；1999年起-至今，南京大学教授。主要从事金属及其配合物的化学生物学研究，在锌离子探针设计、铂类抗肿瘤药物作用机制及靶向传输体系构建等领域取得系统性进展。曾主持多项国家自然科学基金重点项目，科技部973计划重大科学前沿领域项目（首席科学家），国家自然科学基金委创新群体（学术带头人），得到国家基金委化学生物学领域首个重大研究计划培育、集成及择优项目的连续资助以及多项国家自然科学基金重点项目。在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Nat. Commun.等期刊发表论文300余篇，被引用1.9 万次。曾获教育部2015年度自然科学一等奖，意大利化学会2016年度Luigi Sacconi奖章，2020年度“亚洲生物无机化学学会杰出成就奖”等奖项。
论文代表：
Effects of Metal Ions in the Cu-B Center on the Redox Properties of Heme in Heme-Copper Oxidases: Spectroelectrochemical Studies of an Engineered Heme-Copper Center in Myoglobin, Biochemistry, 2005, 44, 1210.
Binding Sites of [Ru(bpy)2(H2O)2](BF4)2 with Sulfur- and Histidine-containing Peptides Studied by Electrospray Ionization Mass Spectrometry and Tandem Mass Spectroscopy, J. Mass Spectrom., 2005, 40, 91. 2004
A Novel Cytotoxic Ternary Copper(II) Complex of 1,10-Phenanthroline and L-Threonine with DNA Nuclease Activity, J. Inorg. Biochem., 2004, 98, 2099.
Novel Cytotoxic Copper(II) Complexes of 8-Aminoquinoline Derivatives: Crystal Structure and Different Reactivity towards Glutathione, Eur. J. Inorg. Chem., 2004, 4028.
A Site-Selective Dual Anchoring Strategy for Artificial Metalloprotein Design, J. Am. Chem. Soc., 2004, 126, 10812.
Oxidative DNA Strand Scission Induced by a Trinuclear Copper(II) Complex, Inorg. Chem., 2004, 43, 4761.
Fast displacement of S,N-chelated L-methionine in platinum(II) complexes by biological thiols, Inorg. Chem. Commun., 2004, 7, 792.
Interaction of palladium(II) and platinum(II) complexes with microperoxidase-11 studied by electrospray mass spectrometry and MS/MS analysis, Inorg. Chem., 2004, 43, 290.
Fluorescent detection of zinc in biological systems: recent development on the design of chemosensors and biosensors, Coord. Chem. Rev., 2004, 248, 205.
Novel polynuclear platinum adducts detected during the reactions of [Pt(Met-S,N)Cl2] with g-glutathione and L-cysteine, J. Inorg. Biochem., 2004, 98, 702.
Crystal structure, DNA-binding ability and cytotoxic activity3 of platinum(II) 2,20-dipyridylamine complexes, Inorg. Chem. Acta, 2004, 357, 95. 2003
Toward the Design of Novel Polynuclear Platinum Antitumor Complexes: A Polydentate Ligand System Based on Dipyridylamine and 1,3,5-Trimethylenebenzene, Inorg. Chem., 2003, 42, 5796.
Novel Au(III) complexes of Aminoquinoline Derivatives: Crystal Structure, DNA Binding and Cytotoxicity Against Melanoma and Lung Tumor cells, Dalton Trans., 2003, 3419.
DNA-Binding Property and Antitumor Activity of Bismuth(III) Complex with 1, 4, 7, 10-Tetrakis(2-pyridylmethyl)-1, 4, 7, 10- tetraazacyclododecane, Dalton Trans., 2003, 2379.
Monofunctional Platinum Complexes Showing Potent Cytotoxicity Against Human Liver Carcinoma Cell Line BEL-7402, J. Med. Chem., 2003, 46, 3502.
New insights into the palladium-mediated selective hydrolysis of the His18-Thr19 peptide bond in cytochrome c: 1H NMR and density functional theory investigated for model compounds, New J. Chem., 2003, 27, 818.
5-fluorouracil-cisplatin adducts with potential antitumor activity, J. Inorg. Biochem., 2003, 94, 186.
Novel Cu(II)-quinoline carboxamide complexes: Structural characterization, cytotoxicity and reactivity towards 5 -GMP, Biometals, 2003, 16, 485.
Crystal structure and superoxide dismutase activity of a six-coordinate manganese(III) complex, Inorg. Chem. Commun., 2003, 6, 262. 2002
Parsons and P.J. Sadler, Chelate ring-opening aminophosphine complexes of ruthenium(II), Inorg. Chim. Acta, 2002, 339, 551.
Theoretical Study of Far-Infrared Spectra of Some Palladium and Platinum Halide Complexes, J. Phys. Chem. A, 2002, 106, 3819.
Investigation of Calix[4]arene-porphyrin and its Palladium(II) and Zinc(II) Complexes at air/water Interface and in langmuir-Blodgett Film, Thin Solid Films, 2002, 413, 224.
Monolayer Formation of Alkyl Chain-Containing Phosphoric Acid Amphilphiles at the Air/Water )pH 5.6) Interface: Influence of Temperature and Cations, J. Colloid Interface Sci., 2002, 246, 335.
Liquid Crystalline Thiadiazole Derivatives: New Ferroelectric Thiadiazole Derivatives, Liquid Crystals, 2002, 29, 199.
A Novel Bis(trans-thiocyanate)iron(II) Spin-Transition Molecular Material with Bidentate Triaryltriazole Ligands and its Bis(cis-thiocyanate)iron(II) Hign-Spin Isomer, Chem. Mater., 2002, 14, 838.
Monitoring the Reactions of the Anticancer Drug Carboplatin with the Chemopreventive Agent Selenomethionine by Electrospray Mass Spectrometry and [1H,15N] HSQC NMR Spectroscopy, Eur. J. Inorg. Chem., 2002, 2170.
Novel Zinc Fluorescent Probe Bearing Dansyl and Aminoquinoline Groups, Chem. Commun., 2002, 1424- 1425.
Structural Evidence for the Facile Chelate-Ring Opening Reactions of Novel Platinum(II)-Pyridine Carboxamide Complexes, J. Chem. Soc., Dalton Trans., 2002, 591. 2001
Titanium(IV) Targets Phosphoesters on Nucleotides: Implications for the mechanism of Action of the Anticancer Drug Titanocene Dicholride, J. Biol. Inorg. Chem., 2001, 6, 698-707.
著作代表：
《生物无机化学》，作者：郭子建、孙为银，科学出版社2018年06月出版；
讲座主题：
《绚丽多彩的化学世界—从元素周期表到生命与艺术的交响》
《金属化学生物学》
邀请老师演讲、授课请致电：19821197419 阎老师[微信同号]
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